Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue

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Schwarz R., Arifler D., Chang S., Pavlova I., Hussain I., Mack V., ...More

OPTICS LETTERS, vol.30, no.10, pp.1159-1161, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 10
  • Publication Date: 2005
  • Doi Number: 10.1364/ol.30.001159
  • Journal Name: OPTICS LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1159-1161
  • Open Archive Collection: AVESIS Open Access Collection
  • Middle East Technical University Northern Cyprus Campus Affiliated: No

Abstract

A ball lens coupled fiber-optic probe design is described for depth-resolved measurements of the fluorescence and reflectance properties of epithelial tissue. A reflectance target, fluorescence targets, and a two-layer tissue phantom consisting of fluorescent microspheres suspended in collagen are used to characterize the performance of the probe. Localization of the signal to within 300 μ m of the probe tip is observed by use of reflectance and fluorescence targets in air. Differential enhancement of the fluorescence signal from the top layer of the two-layer tissue phantom is observed. © 2005 Optical Society of America.